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    This study is retrospective, so it doesn’t prove much about the mechanisms of how these genes are activated. For example, the study is retrospective to the point of making any assumptions in the direction of a particular body composition as a whole or in comparison to other body compositions in an attempt to identify the causative agents causing this phenomenon. The fact is, as far as we can tell, these genes are activated by a mix of hormones, metabolic factors, hormones related to exercise, stress, other factors, and more. As with any experiment, we’ve got to be careful to not extrapolate too much conclusions.

    What it does prove is that one of the mechanisms behind obesity and the loss of muscle mass is that we cannot get the same benefits as we are already getting through proper intake of nutrients that we ingest naturally.

    Source

    Dumosky, R., Langer-Harris, A., & Prentice-Hall, C. (2010). Muscle protein synthesis and maintenance in women. Evidence-Based Complementary and Alternative Medicine, 16, 79-86. doi :10.2307/1541737. PMID 23809962.

    The results of the study were published October 3, 2010 in JAMA Surgery

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